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Lentinula edodes (Shiitake) Modulates Chemically Induced Mutagenesis by Enhancing Pitting

机译：香菇（香菇）通过增强点蚀来调节化学诱导的诱变。

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This study was undertaken to understand how Lentinula edodes modulates in vivo mutagenesis induced by alkylating agents in bone marrow and peripheral blood as described in our previous article. Male Swiss mice were pretreated for 15 consecutive days with aqueous extracts prepared from L. edodes, after which, the number of circulating blood cells, normal erythroid bone marrow cell cycling, and phagocytosis of micronucleated reticulocyte (MNRET) and activation of spleen macrophages were assessed. the results indicate that the antimutagenicity seen in bone marrow and peripheral blood is exerted by distinct compounds with different actions. the antimutagenic effect in bone marrow is exerted by compounds subject to degradation at deep-freeze storage temperature of -20 degrees C. On the other hand, compounds responsible for antimutagenicity in peripheral blood are not subject to degradation at -20 degrees C. the results also indicate that the antimutagenic action in peripheral blood leading to the reduction of circulating MNRET occurs in the spleen primarily through a phagocytic activity due to higher macrophage numbers and probably not due to the enhanced activation state of individual cells.
机译：进行这项研究是为了了解香菇香菇如何调节骨髓和外周血中烷基化剂诱导的体内诱变，如我们先前的文章所述。将雄性Swiss小鼠用香菇提取的水提取物连续预处理15天，然后评估循环血细胞数，正常红系骨髓细胞循环以及微核网织细胞（MNRET）吞噬作用和脾巨噬细胞的活化。结果表明，在骨髓和外周血中观察到的抗致突变性是由具有不同作用的不同化合物发挥的。骨髓中的抗诱变作用是由在-20摄氏度的深冻储存温度下会降解的化合物发挥的。另一方面，负责外周血抗突变性的化合物在-20摄氏度下不会降解。结果也表明在外周血中导致循环MNRET减少的抗诱变作用主要通过吞噬活性而在脾脏中发生，这是由于巨噬细胞数量增加，而不是由于单个细胞的活化状态增强所致。

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